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Quiz: October 2003


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A 38-year-old man referred from the department of psychiatry for sudden appearance of extensive skin lesions...

What's your diagnosis ?

 

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Fixed Drug Eruption (FDE) 

FDEs are usually characterized by a single or a few, sharply demarcated erythematous lesions, but in the most severe form of FDE called “Generalized Bullous Fixed Drug Eruption” (GBFDE), there are symmetric multiple large purplish-livid patches with predilection for the acral extremities and genital areas and usually with sparing the mucosal sites. If widely extensive or close to erythrodermic, it can be easily mistaken for one of the subsets of TEN or Stevens-Johnson syndrome. Absence of constitutional symptoms and rapid recovery without scarring usually help in differentiating GFDE from similar conditions.

 

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