IRANDERMA |
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Quiz: September 2009 |
What is your diagnosis for this 45-year-old man? He referred for evaluating a solitary tumor on his arm. The lesion was asymptomatic and slowly enlarging since 6 months ago. There was no history for any underlying disease and the patient was on no medications.
Diagnosis: PG-like KS or KS-like PG?!
Omid Zargari, MD, FAAD:
Kaposi's sarcoma (KS)-like pyogenic granuloma is a form of pyogenic granuloma closely resembles KS histologically.
It has been reported that immunohistochemistry in such lesions may be positive for smooth muscle actin and factor VIII related antigen, which are typically negative in KS.
It has been shown that in such cases the best way to differentiate KS-like PG from a true KS is to test for the presence of HHV-8 DNA using the polymerase chain reaction (PCR). In such cases caution should be taken not to diagnose solely on the basis of immunohistochemistry phenotype.
ايران درما |